49ers Lose Third Starting Running Back as Isaac Guerendo Exits Game With Apparent Injury [Video]

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and was questionable to return in Sunday’s matchup with the Chicago Bears.

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The 49ers were down to their third-string running back in Guerendo as both Christian McCaffrey and Jordan Mason landed on injured reserve earlier this week.

Prior to Guerendo’s injury, the rookie tallied 15 carries for 78 yards in addition to two catches for 50 yards. Guerendo also recorded two touchdowns in his first game as the lead running back.

Guerendo left to the 49ers locker room with a little over five minutes remaining in the Week 14 matchup.

The saga in San Francisco continues as injuries have ravaged the 49ers squad …